Alcohol Impairment of Immune Function, Host Defense and Tissue Homeostasis

Alcohol Impairment of Immune Function, Host Defense and Tissue Homeostasis (R01)
— Sponsor: National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
— Sponsor Number: PA-15-159
— Deadline Date: 07-May-2017
— Funding Amount: 0.00 USD

** Contact Name : M. Katherine Jung, PhD
** Contact Telephone : 301-443-8744
** Contact Email : jungma@mail.nih.gov
** Program URL : http://grants1.nih.gov/grants/guide/pa-files/PA-15-159.html
** Deadline Dates (ALL) : 07-May-2018, 07-Sep-2017, 07-May-2017, 07-Jan-2018, 05-Feb-2018, 05-Oct-2017, 05-Jun-2017
** Synopsis : SYNOPSIS:

National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites applications from researchers with broad expertise to study the consequences of alcohol consumption on immune function with a goal toward improving the outcome of patients who abuse alcohol. Alcohol abuse has long been associated with increased susceptibility to opportunistic infections. This association has led to extensive research demonstrating that alcohol abuse has a profound and negative impact on immune cell number and function and development of immune defense against pathogens. This pattern of drinking differentially affects the outcome of alcohol abuse: binge alcohol consumption suppresses host innate immune defense; chronic alcohol consumption suppresses most immune functions including phagocytic activity of macrophages and development of adaptive immune defense, yet paradoxically activates chronic inflammation. Cumulative evidence now also supports a role for alcohol-induced immune alterations, in particular inflammation, in a wide range of alcohol related illnesses involving organ or tissue injury. In some cases, interventions against such alcohol-induced immune dysfunctions, such as anti-oxidant supplements and probiotics, are found to be effective in improving the clinical outcome. A comprehensive understanding of alcohol-induced immune dysfunctions and the underlying mechanisms is critical for developing effective diagnostic, preventive, and treatment approaches. This FOA will use the NIH Research Project (R01) award mechanism.

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